ABSTRACT
To evaluate the efficacy and safety of Songling Xuemaikang Capsules combined with conventional Western medicine in the treatment of essential hypertension. PubMed, VIP, CNKI, Wanfang and other databases were retrieved from the establishment of the database to February 2020 for clinical randomized controlled trial(RCT) about Songling Xuemaikang Capsules combined with conventional Western medicine in the treatment of essential hypertension. The literatures were screened out according to the inclusion criteria, and RevMan 5.3 software was used for Meta-analysis. A total of 3 100 patients in 27 RCTs were enrolled. According to Meta-analysis, Songling Xuemaikang Capsules combined with conventional Western medicine could effectively reduce systolic blood pressure(MD=-7.88,95%CI[-9.68,-6.08],P<0.000 01) and diastolic blood pressure(MD=-7.85, 95%CI[-9.07,-6.62], P<0.000 01), triglyceride(MD=-0.46, 95%CI[-0.66,-0.26], P<0.000 01) and total cholesterol(MD=-0.92, 95%CI[-1.49,-0.35], P=0.001), but increase HDL cholesterol(MD=0.51, 95%CI[0.28, 0.73], P<0.000 01), with a better effect than the Western medicine group alone. The results of LDL-C analysis showed that there was no significant difference between the two groups(MD=-0.91, 95%CI[-1.82, 0.01], P=0.05). The subgroup analysis suggested that reduced systolic blood pressure may be related to the use of ARB. There was a close correlation between CCB drugs and the decrease of diastolic blood pressure. In addition, there was no significant difference in the compliance and the incidence of adverse reactions. Clinical application of Songling Xuemaikang Capsules combined with Western medicine in the treatment of patients with essential hypertension has clear efficacy and certain safety. More clinical randomized controlled trials are needed for verification in the future.
Subject(s)
Humans , Angiotensin Receptor Antagonists , Angiotensin-Converting Enzyme Inhibitors , Capsules , Drugs, Chinese Herbal , Essential Hypertension/drug therapyABSTRACT
Objective To establish a HPLC method for determination of the content of catechin in Songling- Xuemaikang capsules. Methods The analysis was performed on Alltima C18 column (250 mm × 4.6 mm, 5 μm) with mobile phase consisting of methanol (A) -l% Acetic Acid (B) for gradient elution. The flow rate was 1 ml/min and the column temperature was 25 ℃. Results The results showed that catechin was well separated with the good linearity in 0.00756-0.05040 μg/μl. The average recovery of catechin was 100.147%. Conclusions The method could be applied to determine catechin in Songling-Xuemaikang capsules, which would make sure the quality control of capsules.
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Objective135 case treatemet of circumgyration originated insufficiency blood of brain of Songling Xuemaikang Jiaonang combined Xuanyunning Pian.MethodsDivided 396 case patient into thee groups:song,ling Xuemaikang Jiaonang group,Xuanyunning Pian group and combined group.songling Xuemaikang Jiaonang group:songling Xuemaikang Jiaonang 1.5g,oral,tid,treatment of 15 days.Xuanyunning Pian group:Xuanyunnings Pian 2 piece,tid,treatment of 15 days.songling Xuemaikang Jiaonang combined Xuanyunning Pian group:songling Xuemaikang Jisonang 1.5g,oral,tid,treatment of 15 days and Xuanyunning Pian 2 piece,tid,treatment of 15 days.And the treatment during three months was observed.ResultsThe effective power of three group were 63.6％(82/129,songling Xuemaikang Jiaonang group),48.5％ (64/132,Xuanyunning Pian group) and 83.7％ ( 113/135,songling Xuemaikang Jiaonang combined Xuanyunning Pian group).Compare songling Xuemaikang Jiaonang group with Xuanyunning Pian group,the effective power were increased significant difference.Compare combined group with songling Xuemaikang Jiaonang group,the effective power were increased very significant difference.ConclusionTreatment of circumgyration originated insufficiency blood of brain,songling Xuemaikang Jiaonang combined Xuanyunning Pian were outweighed than single medication.
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ObjectiveTo observe the influence of Songling Xuemaikang on the hypertension and hemorheology of hyperlipoidemia patients.Methods40 hyperlipoidemia patients randomly divided into Songling Xuemaikang group and jiao gu la zong dai group as a control.The blood lipid and the improvement of hemorheology before and after treatment were compared.ResultsThe efficiency of lipoidemia decrease of treatment and control group is 86.5％and 82.4％,respectively.There was no significant difference between two groups ( P ＞ 0.05 ).The difference of whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,whole blood reduced viscosity and fibrinogen between two groups had significant ( P ＜ 0.05 ).ConclusionSongling Xuemaikang had effect on both regulating blood lipid and improving the several indexes of hemorheology.It could be an effective and safe drug for prevention and cure cardiovascular and cerebrovascular disease.
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Objective To investigate the effect of songling xuemaikang(SL-xmk)pretreatment on the expression of matrix metalloproteinase-9(MMP-9)after focal cerebral ischemia-reperfusion in rats.Methods A total of 45 male Sprague-Dawley rats were randomly allocated into SL-xmk pretreatment,sham operation,and normal saline control group.Preventive gavage was per-formed for 8 weeks in rats using SL-xmk(937.50 mg/kg)suspension in the SLxmk pretreatment group(n = 15);the preventive gavage was performed in rats using the equal volume of normal saline in the sham operation(n = 15)and normal saline control(n = 15)groups.At the end of the pretreatment process,a model of middle cerebral artery occlusion(MCAO)in rats was induced by suture method for 2 hours and reperfusion for 24 hours.The effects of SL-xmk pretreatment on the neurologic deficit scores after transient MCAO,brain water content,and infarct volume in rats were observed.Immunohistochemical staining was used to detect the MMP-9 immunoreactive positive cells in ischemic brain tissue.Results The neurologjc deficit scores(1.21 ± 0.25 vs.2.37 ± 0.35,P = 0.000),the brain water content (76.24% ± 7.09% vs.88.78% ± 6.57%,P = 0.000),the percentage of infarct volume (22.62% ±2.17% vs.27.84% ±3.43%,P =0.000),and the numbers of MMP-9 positive cells(16.20 ± 2.17/mm vs.20.60 ± 2.71/mm,P = 0.000)were all significantly lower than those in the control group.Conclusions SL-xmk pretreatment may significantly inhibit the expression of MMP-9 in the brain tissue of focal cerebral ischemia-reperfusion rats and reduce brain water content and infarct volume.
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Objective To investigate the therapeutic effect of traditional Chinese medicine,Songling Xuemaikang Capsule on the individual with cerebral infarction reconvalescent and its mechanism.Methods Patients in control group( n =54) received regularly therapy and treatment group( n =55) was treated with regularly therapy and Songling Xuemaikang Capsule for eight weeks respectively.The clinical therapeutic effeets,Barthel index,hemorheology indexes,serum lipid and C-reactive protein (CRP) were determined.Results The total clinical effective rate in treatment group and control group was 70.9％ and 55.6％ (P ＜ 0.01 ).After eight weeks treatment,the scores of Barthel Index,hemorheology indexes,the amounts of serum lipid and CRP in treatment group were improved significantly as compared to the control group ( P ＜ 0.05 or P ＜ 0.01 ).There was no severely side effect found in this trial.Conclusion Songling Xuemaikang Capsule could partly improve patients clinical outcome and life quality.The clinical efficacy of Songling Xuemaikang Capsule on the individual with cerebral infarction reconvalescent should be related to its functioning to promote the recovery of patients' blood hemorheology,and regulate serum lipid and decrease CRP level.